Research

Fastaaa – Italian Supercomputing Resource Allocation – Cineca, Iscra C

Mybreathingheart – Regione Toscana Bando Covid19

Imec – Ministero Della Salute Rf 2020-2023

Precise – Regione Toscana Bando Salute Rf 2020-2023

Pensami – Regione Toscana Bando Salute Rf 2020-2023

3D Virtual Baby Heart – Ministero Della Salute Rf 2019-2021

OCT

ValveTech Realization of a polymer aortic valve of new conception and implantable through robotic platform with minimally invasive surgery techniques (2016-2018) Project founded by the Tuscany Region.

K. Capellini et al, 3D printing and 3D virtual models for surgical and percutaneous planning of Congenital Heart Diseases, VISAPP 2020 10.5220/0009160702810287

B.M. Fanni et al, Importance of left atrium fluid dynamics for the planning of LAA closure procedure: an integrated computational fluid dynamics and morphological study, European Heart Journal 2018;39 (Issue Supplement 1):1290 ESC 2018, Munich (ESC Best Poster Awards)

E Vignali, et al A morphological and mechano-biological comparison between ascending thoracic aneurysms with bicuspid and tricuspid valves via in-vivo and ex-vivo investigation. European Heart Journal 2017;38(Suppl. 1):825-826 (P3975) (ESC Travel Awards)

A. Malacarne et al, High-Speed 2D-Scan for Optical Coherence Tomography, 20th Italian National Conference on Photonic Technologies (Fotonica 2018), doi: 10.1049/cp.2018.1656

E. Gasparotti et al, Analysis of non-animal methods and models for research in cardiovascular disease, Biomedical Science and Engineering 2019; volume 3(s3):112, doi: 10.4081/bse.2019.112

M.N. Antonuccio et al, Effects of the distribution in space of the velocity-inlet condition in hemodynamic simulations of the thoracic aorta, Rojas I., Valenzuela O., Rojas F., Herrera L., Ortuño F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2020. Lecture Notes in Computer Science, vol 12108. Springer, Cham, doi: 10.1007/978-3-030-45385-5_6

E. Vignali et al, Development of a fully controllable real-time pump to reproduce left ventricle physiological flow, Carcaterra A., Paolone A., Graziani G. (eds) Proceedings of XXIV AIMETA Conference 2019. AIMETA 2019. Lecture Notes in Mechanical Engineering. Springer, Cham, doi: 10.1007/978-3-030-41057-5_74

A. Mariotti et al, Numerical and experimental uncertainty quantification study of ascending thoracic aortic aneurysm hemodynamics, Carcaterra A., Paolone A., Graziani G. (eds) Proceedings of XXIV AIMETA Conference 2019. AIMETA 2019. Lecture Notes in Mechanical Engineering. Springer, Cham, doi: 10.1007/978-3-030-41057-5_73

G Turini et al, Software Framework for VR-Enabled Transcatheter Valve Implantation in Unity, Lecture Notes in Computer Science, 2019;11613:376-384, doi. 10.1007/978-3-030-25965-5_28

G Turini et al, Patient specific virtual and physical simulation platform for surgical robot movability evaluation in single-access robot-assisted minimally-invasive cardiothoracic surgery, Lecture Notes in Computer Science, 211-220, 2017

L. Landini et al, Registrazione e fusione di immagini multimodali, Capitolo, “Immagini biomediche: nuove tendenze in tecnologia, metodi e applicazioni”, ed. PATRON, 2018 (Capitolo 3, pag: 37-48)

S. Celi and S. Berti, Biomechanics and FE Modelling of Aneurysm: Review and Advances in Computational Models, Aneurysm, Yasuo Murai, IntechOpen, doi: 10.5772/46030

L. Geronzi et al, A novel fast high-fidelity numerical approach based on rbf mesh morphing to evaluate the performances of a polymeric heart valve, ICTAM 2020, in press

M.N. Antonuccio et al, Numerical simulation of blood flow in the thoracic aorta: stochastic sensitivity analysis to inlet velocity spatial distribution, ICTAM 2020

F. Di Bartolo, Penetration Depth Increase of Near Infrared Vortex Light through Turbid Media, CLEO 2020

B.M. Fanni et al, A novel image-based formulation for enhanced patient-specific in silico simulations of cardiovascular interventions, International CAE Conference 2019

K. Capellini et al, A novel FSI approach for the study of the aorta hemodynamics: an integrated imaged based and RBF mesh morphing technique, International CAE Conference 2019

F. Danielli et al, Numerical Model of a Left Atrial Appendage Occluder, International CAE Conference 2019

E. Gasparotti et al, A novel FSI-RBF mesh morphing environment to design a new polymeric aortic valve, International CAE Conference 2019

M.N. Antonuccio et al, An integrated CFD and UQ approach to assess hemodynamic alteration in the Aortic Coarctation, International CAE Conference 2019

E. Vignali et al, In silico evaluation of a patient specific ATAA case through experimental mechano microstructural characterization, International CAE Conference 2019

K. Capellini et al, In-silico assessment of thrombosis risk: a CFD study of left atrial and left atrial appendage, ESB-Ita 2019

K. Capellini et al, A coupled CFD and RBF mesh morphing technique as surrogate for one-way FSI study, ESB-Ita 2019,

B. M. Fanni et al, A corrected formulation for the image-based inferring of patient-specific material properties, ESB-Ita 2019

E. Gasparotti et al, In silico healthcare: first human simulations of Cardioband® procedure for mitral regurgitation, ESB-Ita 2019

E. Vignali et al, Biaxial and optomechanical characterization of soft tissues: a novel setup and experimental tests, ESB-Ita 2019

E. Gasparotti et al, A combined approach of numerical simulation and additive manufacturing technique for in-silico and in-vitro testing of a 3D printing-based aortic polymeric heart valve, SIM AM Proceedings, 2019

B.M. Fanni et al, A numerical and 3D printing framework for the in vivo mechanical assessment of patient-specific cardiovascular structures, SIM AM Proceedings, 2019

A. Mariotti et al, Stochastic analysis of the effect of inlet conditions in the hemodynamics simulation of a thoracic aortic aneurysm, Workshop on Frontiers of Uncertainty Quantification in Fluid Dynamics 11–13 September 2019, Pisa, Italy

M. N. Antonuccio, An integrated approach of uncertainty quantification and 3D MRI techniques in guiding CFD analysis for a non-invasive study of aortic coarctation, Workshop on Frontiers of Uncertainty Quantification in Fluid Dynamics 11–13 September 2019, Pisa, Italy

A. Zaccaria et al, A validation path for a Left Atrial Appendage Occluder, VPH, Parigi, Francia

E. Vignali et al, Development of a custom mock circulatory loop for in-vitro study of patient specific aortic branch, ISMCS 2019, Bologna, Italy

D. Haxhiademi et al, Platelet function tests in VA ECMO patients – Can we read between the lines? ISMCS 2019, Bologna, Italy

B.M. Fanni et al, Indirect evaluation of material properties of large blood vessels based on in silico and in vitro models, ESB 2019 Congress

F. Di Bartolo et al, Optomechanical characterization of soft biological tissues: an integration of biaxial test and sals technique, ESB 2019 Congress

B.M. Fanni et al, A modified formulation of the QA method for inferring materials properties for enhanced patient-specific computational models, BioMedEng 2019

C. Groth et al, The medical digital twin assisted by Reduced Order Models and Mesh Morphing, International CAE conference and exibition, 2018, Vicenza, Italy

F. Falconi, High-Speed 2D-Scan for Optical Coherence Tomography, Fotonica AEIT Italian conference on photonics technologies, 2018

B.M. Fanni et al, 3D printed models for the mechanical characterization of cardiovascular structures, Proceedings of IDBN 2018, pp. 54-56

E. Vignali et al, 3D Printing of an antibiotic-loaded heart valve ring prosthesis in thermoplastic polyurethane: fabrication, testing and simulation, Proceedings of IDBN 2018, pp. 60-62

Z. Manigrasso et al, Design of a novel 3D printed mock cardiac pump: in-silico and experimental evaluation, Proceedings of IDBN 2018, pp. 57-59

Z. Manigrasso et al, A novel 3D printed bioinspired cardiac pneumatic pump: from design to numerical and experimental study, VPH 2018, Zaragoza, Spain, 2018

B.M. Fanni et al, An integrated image-based framework for the mechanical characterization of patient-specific blood vessels, VPH 2018, Zaragoza, Spain, 2018

E. Vignali et al, Towards non-invasive assessment of human aortic tissue microstructure: Diffusion Tensor Imaging for collagen fiber detection, GNB, Milano, 2018, pp: 1-4

E. Vignali et al, Ascending thoracic aortic FE simulation by integrating patient-specific data from imaging, mechanical properties and histological data, WCB 2018

E. Gasparotti et al, Towards a patient-specific finite element simulation of Cardioband procedure for the treatment of mitral regurgitation, WCB 2018

B.M. Fanni et al, Image-based mechanical characterization of large blood vessels for patient-specific simulations, WCB 2018

A. Boccadifuoco, A. Mariotti, K. Capellini, S. Celi, M.V. Salvetti, Impact of uncertainties in inlet conditions on the hemodynamic simulation in ascending thoracic aortic aneurysms, WCB 2018

E. Gasparotti et al, Melt Compounded Biocompatible Thermoplastic Polyurethane (TPU) for the Engineering of 3D printed Aortic Heart Valve Ring: Design, Fabrication, Testing and Simulation, ISBPPB 2018

E Vignali, K Capellini, P Losi, M Murzi, PA Farneti, V Positano, L Landini, S Celi. A morphological and histo-mechanical study for ascending aorta aneurisms in BAV and TAV patients. 23rd Congress of the European Society of Biomechanics, July 2 – 5, 2017, Seville, Spain

E Gasparotti, E Vignali, K Capellini, G Vivoli, AG Cerillo, V Positano, S Berti, L Landini, S Celi. A FE tool to simulate a trans-catheter anchor-based system for mitral valve regurgitation. Proceedings of the VII Annual Meeting Italian Chapter of the European Society of Biomechanics 2017:57

BM Fanni, E Gasparotti, S Celi, V Positano, F Faita, N Di Lascio, L Landini, S Schievano, C Capelli. Image-based mechanical characterization of large blood vessels. Proceedings of the VII Annual Meeting Italian Chapter of the European Society of Biomechanics 2017:35

S. Porziani et al, Hemo-Elastic study of ascending thoracic aorta aneurysms through RBF mesh morphing, CAE Conference 2018

G Vivoli, E Gasparotti, M Rezzaghi, M Mariani, V Positano, S Berti, L Landini, S Celi. 3D left atrial appendage modelling: a multimodal imaging approach. Proceedings of the VII Annual Meeting Italian Chapter of the European Society of Biomechanics 2017:59

K Capellini, E Costa, ME Biancolini, E Vignali, V Positano, L Landini, S Celi. An image-based and RBF mesh morphing CFD simulation for aTAA hemodynamic. Proceedings of the VII Annual Meeting Italian Chapter of the European Society of Biomechanics 2017:25

AG Cerillo, T Gasbarri, S Celi, M Murzi, G Trianni, M Ravani, M, Solinas, S Berti, Transapical Transcatheter Valve-in-Valve Implantation for Failed Mitral Bioprostheses: Gradient, Symptoms, and Functional Status in 18 High-Risk Patients Up to 5 Years, Ann Thorac Surg. 2016, 102(4):1289-95.

Celi S, Berti S., Three-dimensional sensitivity assessment of thoracic aortic aneurysm wall stress: a probabilistic finite-elementstudy. Eur J Cardiothorac Surg. 2014, 45(3):467-75

Celi S, Berti S., In-vivo segmentation and quantification of coronary lesions by optical coherence tomography images for a lesion type definition and stenosis grading. Med Image Anal. 2014, 18(7): 1157-68

Celi S, Vaghetti M, Palmieri C, Berti S., Coronary calcium analysis by OCT: looking forward an imaging algorithm for an automatic 3D quantification. Int J Cardiol. 2013, 168(3): 2958-60

The goal of this project is to develop a framework to optimize the 3D visualization and quantification of high resolution USPA imaging. In particular: design, implementation and validation of ML tools for USPA image segmentation, visualization and quantification. The project is part of an extraordinary industrial experience with possibility to assist in-vivo experiments with the USPA technology in our lab in Amsterdam. You will be working closely with a PhD student and R&D manager. Due to current travel restrictions, we can start remotely and with possibility in the near future to visit us at the European Headquarters in Amsterdam. Further details can be found in the following links:

links:

VisualSonics
MgSAFE

• Marilena Mazzoli – Sviluppo di sistemi intelligenti per lo studio della fluidodinamica cardiovascolare mediante reti physically based
• Stefano Quartieri – Sviluppo di un banco prova per bulge test
• Chiara D’Alessandro – Shape analysys and FSI dell’LAA
• Margherita Giannoni – FSI dell’atrio sinistro
• Edoardo Cheli – studio di sensibilità ai parametri di input mediante tecniche di UQ
• Gabriele Gallo – Analisi CFD della fluidodinamica della carotide mediante tecniche di UQ
• Chiara Carabelli – Simulazione numerica del sistema ECMELLA
• Francesca Dell’Agnello – Tecniche di mesh morphing applicate alla CT
• Beatrice Donati – Studio delle condizioni di inlet dell’aorta mediante CT gated del ventricolo sinistro
• Mariarita Vottari – Studio della rigidezza del tessuto aortico da imaging dinamico (CT) mediante tecniche di mesh morphing o inverse FEM
• Giulia Tosto – Studio in-vitro del gradiente transvalvolare della valvola mitralica patologica e della sua correzione post Mitraclip
• Claudia Plutino – Studio dell’effetto del dispositivo percutaneo Cardioband sulla riduzione del rigurgito della valvola tricuspide
• Eleonora Storto – Studio della fluidodinamica dell’aorta su banco prova attraverso la tecnica PIV (Particle Image Velocimetry)
• Giulia Tosto – Studio in-vitro del gradiente transvalvolare della valvola mitralica patologica e della sua correzione post Mitraclip
• Lucia Giuggioli – Studio dell’emodinamica degli aneurismi dell’aorta addominale mediante simulazioni CFD e tecniche di mesh morphing

• Silvio Centonze: Studio CFD dell’influenza delle condizioni di inlet nella sezione della valvola artica sulla fluidodinamica coronarica in Ambiente SinVascular mediante tecniche UQ
• Serena Prizio – Strategie di unloading del ventricolo sinistro nell’ECMO veno-arterioso periferico: simulazione su banco-prova (Tesi Specializzazione in Anestesia, Rianimazione, Terapia Intensiva e del Dolore)
• Federica Giovannini – Caratterizzazione meccanica e funzionale dei materiali della stampante 3D Stratasys J750 Digital Anatomy per il settore vascolare
• Raffaella Erario – Studio della fluidodinamica della procedura di shunt modificato di Blalock-Taussig mediante simulazioni CFD
• Nicola Bechini – Effects of the Cardioband procedure on the mitral valve
• Alessandro Benvenuti – Analisi degli effetti delle vene polmonari sulla fluidodinamica dell’auricola sinistra mediante simulazioni numeriche agli elementi finiti
• Eleonora Del Pia: Studio degli effetti di procedura di chiusura dell’auricola sinistra tramite simulazioni di fluidodinamica computazionale
• Miriana Pititto: Quantificazione dell’incertezza delle proprietà meccaniche per analisi numeriche fluido-strutturali di grandi vasi
• Michela Caridi – Simulazione numerica della procedura ECMO
• Simone Garzia: Automated 3D aortic segmentation of 4D flow MRI using deep learning
• Aurelia Lamia: Simulazione numerica agli elementi finiti della procedura Cardioband® per la correzione del rigurgito mitralico
• Sergio Longo: Graph Neural Networks as surrogate for thoracic aortic aneurysm wall shear stress estimation
• Claudia Angeletti: Development and implementation of a ROM-based strategy for fast aortic flow hemodynamics evaluation
• Sandra Perondi: Studio della fluidodinamica della coartazione aortica mediante tecniche CFD e stocastiche
• Niccolò Mori: Circulatory mock loop for thoracic aorta hemodynamics analysis: stochastic sensitivity to inlet conditions and comparison with numerical simulations results (Ingegneria Aerospaziale)

2020

• Massimo Scolaro – Simulazione su banco prova dell’interazione cuore – ECMO veno-arterioso periferico (Tesi Specializzazione in Anestesia, Rianimazione, Terapia Intensiva e del Dolore)
• Enrico Vignali: Emodinamica dell’aorta toracica: effetto delle condizioni di inlet su esperimenti e simulazioni (Ingegneria Aerospaziale).
• Elisa Benelli: Studio dell’aggregazione piastrinica in condizioni di alto shear stress: confronto tra test basati su agonisti solubili ed attivazione spontanea (UNIPR)
• Maria Teresa Marino: Sviluppo di un simulatore fluido-dinamico per la valutazione del flusso coronarico attraverso risonanza magnetica ad alto campo.
• Roberta Tralongo: Sviluppo e implementazione di un workflow per l’analisi di immagini retiniche di Angio-OCT
• Andrea Baldini: Study of a cohort of patients affected by Tetralogy of Fallot: an integrated approach between numerical simulation and experimental activities.

2019

• Leonardo Geronzi: Development of a fast high fidelity FSI workflow to simulate polymeric aortic valves: a RBF mesh morphing study
• Bernardo Alunno Rossetti: Numerical investigation of a parametric model for the material characterization of great vessels
• Ilaria Ricci: Sviluppo e implementazione di un modello 4D di condizioni al contorno di ingresso per lo studio della fluidodinamica cardiovascolare
• Michele Corti: Development of an in silico and an in vitro workflow for the planning of cerebral aneurysms intervention: an integrated approach with echo-PIV and CFD (with INSERN)
• Federica Poli: Progettazione e realizzazione di un banco prova per la caratterizzazione optomeccanica del tessuto vascolare
• Maria Nicole Antonuccio: Towards the translation of patient-specific simulations into clinics: an integrated approach in guiding CFD analysis for a non-invasive study of aortic coarctation (with UCL)
• Marianna D’Amico: Modellizzazione di immagini LGE di risonanza magnetica cardiaca per lo sviluppo di algoritmi automatici di segmentazione di regioni fibrotiche
• Davide Giannetti: Sviluppo di un algoritmo di tracking per immagini ecografiche per lo studio funzionale della valvola mitrale pre e post impianto di chiusura dell’auricola sinistra.

2018

• Valeria Grasso: Unsupervised analysis of phase contrast MRI by maximally stable extremal region algorithm for patient-specific tissue characterization (with UCL)
• Giulia Barondi: Sviluppo di un banco prova fluidodinamico per lo studio funzionale di protesi valvolari
• Alice Covelli: Valutazione delle alterazioni fluidodinamiche dell’atrio destro mediante analisi computazionale
• Mario di Leonardo: Sviluppo di modelli in silico per l’analisi morfologica e funzionale dell’auricola sinistra mediante simulazioni numeriche CFD
• Dario Sabatino: Planning dell’intervento di chiusura della auricola sinistra mediante approccio integrato di tecniche di imaging e analisi FEM
• Zaira Manigrasso: Mock cardiac pump compatible with magnetic resonance imaging: design, simulation and fabrication (with UCL)

2017

• Benigno Marco Fanni: Image-based mechanical characterization of large blood vessels: a combined approach of experimental and computational tools (with UCL)